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Maturity Onset Diabetes Of The Young (MODY)

   

Maturity Onset Diabetes Of The Young (MODY)Maturity Onset Diabetes Of The Young (MODY)
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Maturity Onset Diabetes Of The Young (MODY) is a rare, inherited kind of diabetes mellitus, which occurs from a mutation in a single gene in one’s DNA that helps regulate the production of insulin. Insulin is a hormone that is needed to help glucose get from your blood into your body’s cells to produce energy. Glucose is sugar that your body gets from the food you eat.

Maturity Onset Diabetes Of The Young is a dominant genetic, lifelong condition. If any of the parents has this specific gene mutation, their children have a 50% chance of inheriting it from them and if that happens, the children most likely will develop MODY regardless of their lifestyle, ethnic group, or weight. In many cases, the disease reaches across more than one generation, affecting adolescents and young adults before they reach 25 years of age.

The symptoms of MODY usually appear slowly and resemble those of both type 1 and type 2 diabetes. Sometimes, the symptoms do not show at all, depending on what gene is affected. Among the signs of MODY are high blood sugar, excessive hunger and thirst, frequent urination, weight loss, blurry vision, recurring skin and yeast infections, and fatigue.

Because of MODY’s similarities in clinical appearance with other types of diabetes, up to 95% of Maturity Onset Diabetes Of The Young get misdiagnosed as type 1 and type 2 diabetes. As the first step in diagnosing MODY, your doctor may take a blood sugar test. If the result indicates diabetes, the doctor has to determine what type of diabetes you have by taking into consideration your family history, a combination of symptoms and additional tests, including a genetic test, by which MODY can be diagnosed. The genetic test will help to find out if there is a mutation in one of the genes and therefore, determine if you have MODY, as well as the exact type of MODY that you have, all of which can be accomplished even before you develop any symptoms. Getting the right diagnosis is very important because treatments for type 1 and type 2 diabetes as well as for different types of MODY can vary significantly.

The effective treatment for MODY 1, 3, and 4 is sulfonylureas – a diabetic drug that boosts insulin production in pancreas. MODY 3 can be initially controlled with diet and later treated with sulfonylureas and then eventually  with insulin. In some cases, insulin injections can be a better treatment for people diagnosed with MODY 1 and 4 as well.

MODY 2 is the mildest form Maturity Onset Diabetes Of The Young. It can be successfully treated with exercise and diet and no medications are usually needed.

The treatment for MODY 5 and 6 is insulin. MODY 5 is one of the rarest and most dangerous forms Maturity Onset Diabetes Of The Young. It may damage internal organs, such as kidneys, and a proper treatment for complications like kidney failure and kidney cysts might be necessary. MODY 6 is also very rare, but it mostly develops at about 40 years of age.

Other types of MODY have been discovered relatively recently and require more studies to be conducted to determine the most possible outcomes as well as the best treatment options.

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